Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology.

ABSTRACT:

Background

Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer's disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune effectors. We previously showed that regulatory T cells (Tregs) have a beneficial impact on disease progression in AD-like pathology, notably by modulating the microglial response associated with Aβ deposits in a mouse model of amyloid pathology. Besides microglia, reactive astrocytes also play a critical role in neuroinflammatory processes associated with AD. Different phenotypes of reactive astrocytes have previously been characterized, including A1-like neurotoxic and A2-like neuroprotective subtypes. However, the precise impact o

SUBMITTER: Stym-Popper G 

PROVIDER: S-EPMC9996941 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature