Molecular mechanism and diagnostic marker investigation of endoplasmic reticulum stress on periodontitis.

ABSTRACT:

Purpose

The aim of this study was to reveal the biological function of endoplasmic reticulum stress (ERS)-related genes (ERSGs) in periodontitis, and provide potential ERS diagnostic markers for clinical therapy of periodontitis.

Methods

The differentially expressed ERSGs (DE-ERSGs) were reveled based on periodontitis-related microarray dataset in Gene Expression Omnibus (GEO) database and 295 ERS in previous study, followed by a protein-protein interaction network construction. Then, the subtypes of periodontitis were explored, followed by validation with immune cell infiltration and gene set enrichment. Two machine learning algorithms were used to reveal potential ERS diagnostic markers of periodontitis. The diagnostic effect, target drug and immune correlation of these ma

SUBMITTER: Sun Q 

PROVIDER: S-EPMC9996967 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature