IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans.

ABSTRACT:

Background

IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial cell differentiation and proliferation, giving it the potential to modulate the microbiome through these direct and indirect effects. Furthermore, the microbiome can in turn influence IL-22 production through the synthesis of L-tryptophan (L-Trp)-derived AhR ligands, creating the prospect of a host-microbiome feedback loop. We evaluated the impact IL-22 may have on the gut microbiome and its ability to activate host AhR signaling by observing changes in gut microbiome composition, function, and AhR ligand production following exogenous IL-22 treatment in both mice

SUBMITTER: Mar JS 

PROVIDER: S-EPMC9997005 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature