Degradable Fe₃O₄-based nanocomposite for cascade reaction-enhanced anti-tumor therapy.

ABSTRACT: Cascade catalytic therapy has been recognized as a promising cancer treatment strategy, which is due in part to the induced tumor apoptosis when converting intratumoral hydrogen peroxide (H₂O₂) into highly toxic hydroxyl radicals (˙OH) based on the Fenton or Fenton-like reactions. Moreover this is driven by the efficient catalysis of glucose oxidization associated with starving therapy. The natural glucose oxidase (GO _x ), recognized as a "star" enzyme catalyst involved in cancer treatment, can specially and efficiently catalyze the glucose oxidization into gluconic acid and H₂O₂. Herein, pH-responsive biodegradable cascade therapeutic nanocomposites (Fe₃O₄/GO _x -PLGA) with dual enzymatic

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9997073 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature