Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies.

ABSTRACT:

Background

Ischaemic brain infarction can occur without acute neurological symptoms (covert strokes) or with symptoms (overt strokes), both associated with poor health outcomes. We conducted a pilot study of the incidence of preoperative and postoperative (intraoperative or postoperative) covert strokes, and explored the relationship of postoperative ischaemic brain injury to blood levels of neurofilament light, a biomarker of neuronal damage.

Methods

We analysed 101 preoperative (within 2 weeks of surgery) and 58 postoperative research MRIs on postoperative days 2-9 from two prospective cohorts collected at the University of Wisconsin (NCT01980511 and NCT03124303). Participants were aged >65 yr and undergoing non-intracranial, non-carotid surgery.

Results

Preoperativ

SUBMITTER: Taylor J 

PROVIDER: S-EPMC9997085 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature