Asymmetric amyloid deposition in preclinical Alzheimer's disease: A PET study.

ABSTRACT:

Introduction

The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer's disease (AD) is that of a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed in early stages of AD. Aβ distribution on PET has previously been explored in MCI and AD, but it has yet to be directly investigated in preclinical AD (pAD). We examined how Aβ was distributed in individuals with pAD and MCI using ¹¹C-Pittsburgh Compound B (PiB) PET.

Methods

In this PET study, 79 subjects were retrospectively enrolled, including 34 controls, 24 pAD, and 21 MCI. All subjects underwent APOE genotyping, ¹¹C-PiB PET, MRI, and cognitive testing. We explored differences in Aβ load, Aβ lateralisation, and Aβ distribution, as well as associations

SUBMITTER: Kjeldsen PL 

PROVIDER: S-EPMC9997142 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature