Capillary function progressively deteriorates in prodromal Alzheimer's disease: A longitudinal MRI perfusion study.

ABSTRACT: Cardiovascular risk factors are associated with the development of Alzheimer's disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance imaging, we investigated the two-year changes of the cerebral microvascular blood flow in 11 mild cognitively impaired (MCI) patients with prodromal AD compared to 12 MCI patients without evidence of AD and 10 cognitively intact age-matched controls. The pAD-MCI patients displayed widespread deterioration in microvascular cerebral perfusion associated with capillary dysfunction. No such changes were observed in the other two groups, suggesting that the dysfunction in capillary perfusion is linked to the AD pathophysiology. The observed capillary dysfunctio

SUBMITTER: Madsen LS 

PROVIDER: S-EPMC9997144 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature