Scoping review of disease-modifying effect of drugs in experimental epilepsy.

ABSTRACT:

Objective

Epilepsy affects ~50 million people worldwide causing significant medical, financial, and sociologic concerns for affected patients and their families. To date, treatment of epilepsy is primarily symptomatic management because few effective preventative or disease-modifying interventions exist. However, recent research has identified neurobiological mechanisms of epileptogenesis, providing new pharmacologic targets to investigate. The current scientific evidence remains scattered across multiple studies using different model and experimental designs. The review compiles different models of anti-epileptogenic investigation and highlights specific compounds with potential epileptogenesis-modifying experimental drugs. It provides a platform for standardization of future epil

SUBMITTER: Ots HD 

PROVIDER: S-EPMC9997527 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature