Extensive set of African ancestry-informative markers (AIMs) to study ancestry and population health.

ABSTRACT: Introduction: Human populations are often highly structured due to differences in genetic ancestry among groups, posing difficulties in associating genes with diseases. Ancestry-informative markers (AIMs) aid in the detection of population stratification and provide an alternative approach to map population-specific alleles to disease. Here, we identify and characterize a novel set of African AIMs that separate populations of African ancestry from other global populations including those of European ancestry. Methods: Using data from the 1000 Genomes Project, highly informative SNP markers from five African subpopulations were selected based on estimates of informativeness (In) and compared against the European population to generate a final set of 46,737 African ancestry-inf

SUBMITTER: Boudeau S 

PROVIDER: S-EPMC9997643 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature