Identification of genes influencing the evolution of Escherichia coli ST372 in dogs and humans.

ABSTRACT: ST372 are widely reported as the major Escherichia coli sequence type in dogs globally. They are also a sporadic cause of extraintestinal infections in humans. Despite this, it is unknown whether ST372 strains from dogs and humans represent shared or distinct populations. Furthermore, little is known about genomic traits that might explain the prominence of ST372 in dogs or presence in humans. To address this, we applied a variety of bioinformatics analyses to a global collection of 407 ST372 E. coli whole-genome sequences to characterize their epidemiological features, population structure and associated accessory genomes. We confirm that dogs are the dominant host of ST372 and that clusters within the population structure exhibit distinctive O:H types. One phylogenetic clus

SUBMITTER: Elankumuran P 

PROVIDER: S-EPMC9997745 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature