Population-based real-world registry study to evaluate clinical outcomes of chronic graft-versus-host disease.

ABSTRACT:

Introduction

Chronic graft-versus-host disease (cGVHD) is a serious immune-mediated complication after allogeneic haematopoietic stem cell transplantation (HSCT), but in patients with malignancy, cGVHD development is associated with superior survival. Lack of reliable biomarkers and clinical underreporting means there is insufficient understanding of cGVHD clinical outcomes and balance between cGVHD treatment and maintaining beneficial graft-versus-tumour effects.

Methods

We performed a Swedish population-wide registry study following patients who underwent allogeneic HSCT 2006-2015. cGVHD status was retrospectively classified using a real-world method based on the timing and extent of systemic immunosuppressive treatment.

Results

cGVHD incidence among patients surviv

SUBMITTER: Novitzky-Basso I 

PROVIDER: S-EPMC9997892 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature