Diagnostic performance of two rapid tests for syphilis screening in people living with HIV in Cali, Colombia.

ABSTRACT:

Introduction

There is insufficient evidence supporting the use of rapid diagnostic tests (RDTs) for syphilis in people living with HIV (PLWH). We evaluated the diagnostic performance of two commercially available RDTs (Bioline and Determine) in PLWH in Cali, Colombia.

Methods

A cross-sectional field validation study on consecutive adults with confirmed HIV diagnosis attending three outpatient clinics. Both RDTs were performed on capillary blood (CB), obtained by finger prick, and sera, by venipuncture. A combination of treponemal enzyme linked immunosorbent assay (ELISA) and Treponema pallidum haemagglutination assay (TPHA) on serum samples was the reference standard. Rapid plasma reagin (RPR) and clinical criteria were added to define active syphilis. Sensitivity and specif

SUBMITTER: Garcia Luna JA 

PROVIDER: S-EPMC9997911 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature