Serum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue.

ABSTRACT:

Background

Dengue is the most common vector-borne viral disease worldwide. Most cases are mild, but some evolve into severe dengue (SD), with high lethality. Therefore, it is important to identify biomarkers of severe disease to improve outcomes and judiciously utilize resources.

Methods/principal findings

One hundred forty-five confirmed dengue cases (median age, 42; range <1-91 years), enrolled from February 2018 to March 2020, were selected from an ongoing study of suspected arboviral infections in metropolitan Asunción, Paraguay. Cases included dengue virus types 1, 2, and 4, and severity was categorized according to the 2009 World Health Organization guidelines. Testing for anti-dengue virus IgM and IgG and serum biomarkers (lipopolysaccharide binding protein and chymas

SUBMITTER: Bernal C 

PROVIDER: S-EPMC9997924 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature