Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders.

ABSTRACT:

Background

Genetic factors contribute to individual differences in the severity of coronavirus disease 2019 (COVID-19). A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals.

Methods

Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates.

Findings

SUBMITTER: Waszczuk MA 

PROVIDER: S-EPMC9997960 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature