Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

ABSTRACT: Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites. Pcm1^-/- mice display partially penetrant perinatal lethality with survivors exhibiting hydrocephalus, oligospermia, and cerebellar hypoplasia, and variably expressive phenotypes such as hydronephrosis. As many of these phenotypes have been observed in human ciliopathies and satellites are implicated in cilia biology, we investigated whether cilia were affected. PCM1 was dispensable for ciliogenesis in many cell types, whereas Pcm1^-/- multiciliated ependymal cells and human PCM1^-/- retinal pigm

SUBMITTER: Hall EA 

PROVIDER: S-EPMC9998092 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature