Dataset Information
LAVAA: a lightweight association viewer across ailments.
Ontology highlight
ABSTRACT: Motivation
Biobank scale genetic associations results over thousands of traits can be difficult to visualize and navigate.Results
We have created LAVAA, a visualization web-application to generate genetic volcano plots for simultaneously considering the P-value, effect size, case counts, trait class and fine-mapping posterior probability at a single-nucleotide polymorphism (SNP) across a range of traits from a large set of genome-wide association study. We find that user interaction with association results in LAVAA can enrich and enhance the biological interpretation of individual loci.Availability and implementation
LAVAA is available as a stand-alone web service (https://geneviz.aalto.fi/LAVAA/) and will be available in future releases of the finngen.fi website starting with release 10 in late 2023.
SUBMITTER: Fauman EB
PROVIDER: S-EPMC9998102 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
LAVAA: a lightweight association viewer across ailments.
Bioinformatics advances 20230215 1
<h4>Motivation</h4>Biobank scale genetic associations results over thousands of traits can be difficult to visualize and navigate.<h4>Results</h4>We have created LAVAA, a visualization web-application to generate genetic volcano plots for simultaneously considering the <i>P</i>-value, effect size, case counts, trait class and fine-mapping posterior probability at a single-nucleotide polymorphism (SNP) across a range of traits from a large set of genome-wide association study. We find that user i ...[more]