LAVAA: a lightweight association viewer across ailments.

ABSTRACT:

Motivation

Biobank scale genetic associations results over thousands of traits can be difficult to visualize and navigate.

Results

We have created LAVAA, a visualization web-application to generate genetic volcano plots for simultaneously considering the P-value, effect size, case counts, trait class and fine-mapping posterior probability at a single-nucleotide polymorphism (SNP) across a range of traits from a large set of genome-wide association study. We find that user interaction with association results in LAVAA can enrich and enhance the biological interpretation of individual loci.

Availability and implementation

LAVAA is available as a stand-alone web service (https://geneviz.aalto.fi/LAVAA/) and will be available in future releases of the finngen.fi we

SUBMITTER: Fauman EB 

PROVIDER: S-EPMC9998102 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature