Prenatal trimester-specific intake of micronutrients: global DNA methylation and hydroxymethylation at birth and persistence in childhood.

ABSTRACT: The prenatal environment may program health and disease susceptibility via epigenetic mechanisms. We evaluated associations of maternal trimester-specific intake of micronutrients with global DNA methylation (%5mC) and 5-hydroxymethylation (%5hmC) at birth in cord blood and tested for persistence into childhood. We quantified global %5mC and %5hmC in cord blood cells (n = 434) and in leukocytes collected in early (n = 108) and mid-childhood (n = 390) from children in Project Viva, a pre-birth cohort from Boston, MA. Validated food frequency questionnaires estimated maternal first- and second-trimester intakes of vitamin B₂, vitamin B₆, vitamin B₁₂, folate, betaine, choline, methionine, iron, and zinc. Mean (SD) cord blood %5mC and %5hmC

SUBMITTER: Parsons E 

PROVIDER: S-EPMC9998337 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature