An external exposome-wide association study of opioid use disorder diagnosed during pregnancy in Florida.

ABSTRACT: The prevalence of opioid use disorder (OUD) during pregnancy has quadrupled in recent years and widely varies geographically in the US. However, few studies have examined which environmental factors are associated with OUD during pregnancy. We conducted an external exposome-wide association study (ExWAS) to investigate the associations between external environmental factors and OUD diagnosed during pregnancy. Data were obtained from a unique, statewide database in Florida comprising linked individual-level birth and electronic health records. A total of 255,228 pregnancies with conception dates between 2012 and 2016 were included. We examined 82 exposome measures characterizing seven aspects of the built and social environment and spatiotemporally linked them to each individual record. A t

SUBMITTER: Lin B 

PROVIDER: S-EPMC9998369 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature