Ontology highlight
ABSTRACT:
SUBMITTER: Portela-Lomba M
PROVIDER: S-EPMC9998535 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Portela-Lomba María M Simón Diana D Fernández de Sevilla David D Moreno-Flores Mª Teresa MT Sierra Javier J
Frontiers in molecular neuroscience 20230224
An approach to generate new neurons after central nervous system injury or disease is direct reprogramming of the individual's own somatic cells into differentiated neurons. This can be achieved either by transduction of viral vectors that express neurogenic transcription factors and/or through induction with small molecules, avoiding introducing foreign genetic material in target cells. In this work, we propose olfactory ensheathing glia (OEG) as a candidate for direct reprogramming to neurons ...[more]