Evaluating the association between DNM1L variants and Parkinson's disease in the Chinese population.

ABSTRACT:

Introduction

Parkinson's disease (PD) is a progressive movement disorder caused by a loss of dopaminergic neurons. Previous studies have highlighted the importance of mitochondria dynamics in the pathogenesis of PD. Dynamin-1-like (DNM1L) is a gene that encodes dynamin-related protein 1 (DRP1), a GTPase essential for proper mitochondria fission. In the present study, we evaluated the relationship between DNM1L variants and PD in the Chinese population.

Methods

A total of 3,879 patients with PD and 2,931 healthy controls were recruited and burden genetic analysis combined with high-throughput sequencing was applied.

Results

We identified 23 rare variants in the coding region of DNM1L, while no difference in variant burden was shown between the case

SUBMITTER: Liu J 

PROVIDER: S-EPMC9998701 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature