The impact of specific pulmonary arterial hypertension therapy on cardiac fluorodeoxyglucose distribution in PET/MRI hybrid imaging-follow-up study.

ABSTRACT:

Background

PET/MRI hybrid imaging in pulmonary arterial hypertension (PAH) provides important prognostic information identifying patients who might benefit from early therapy escalation, as right ventricle (RV) metabolic alterations are linked with hemodynamics and might precede clinical deterioration. Now, we hypothesize that adequate PAH therapy escalation may result in reversal of unfavourable increased glucose uptake of RV, which is associated with improved prognosis.

Methods

Out of twenty-six initially clinically stable PAH patients who had baseline PET/MRI scans, twenty (49.9 ± 14.9 years) had second PET/MRI after 24 months. SUV_RV/SUV_LV ratio was used to estimate and compare cardiac glucose uptake. Occurrences of clinical endpoints (CEP), defined

SUBMITTER: Kazimierczyk R 

PROVIDER: S-EPMC9998792 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature