Characteristics of the fecal microbiome and metabolome in older patients with heart failure and sarcopenia.

ABSTRACT:

Background

Increasing evidence supports that gut microbiota plays an important role in the development of cardiovascular diseases. The prevalence of sarcopenia is increasing in patients with heart failure. Muscle wasting is an independent predictor of death in heart failure patients.

Aims

In this study, we aimed to explore the characteristics of gut microbiota and metabolites in heart failure patients with or without sarcopenia.

Methods

Fecal samples of 33 heart failure patients without sarcopenia, 29 heart failure patients with sarcopenia, and 15 controls were collected. The intestinal microbiota was analyzed using 16S rRNA sequencing and the metabolites were detected using the gas chromatography-mass spectrometry method.

Results

There were significant differe

SUBMITTER: Peng J 

PROVIDER: S-EPMC9998919 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature