Dataset Information

Effect of the chronic medication use on outcome measures of hospitalized COVID-19 patients: Evidence from big data.

ABSTRACT:

Background

Concerns about the role of chronically used medications in the clinical outcomes of the coronavirus disease 2019 (COVID-19) have remarkable potential for the breakdown of non-communicable diseases (NCDs) management by imposing ambivalence toward medication continuation. This study aimed to investigate the association of single or combinations of chronically used medications in NCDs with clinical outcomes of COVID-19.

Methods

This retrospective study was conducted on the intersection of two databases, the Iranian COVID-19 registry and Iran Health Insurance Organization. The primary outcome was death due to COVID-19 hospitalization, and secondary outcomes included length of hospital stay, Intensive Care Unit (ICU) admission, and ventilation therapy. The Anatomical Therapeutic Chemical (ATC) classification system was used for medication grouping. The frequent pattern growth algorithm was utilized to investigate the effect of medication combinations on COVID-19 outcomes.

Findings

Aspirin with chronic use in 10.8% of hospitalized COVID-19 patients was the most frequently used medication, followed by Atorvastatin (9.2%) and Losartan (8.0%). Adrenergics in combination with corticosteroids inhalants (ACIs) with an odds ratio (OR) of 0.79 (95% confidence interval: 0.68-0.92) were the most associated medications with less chance of ventilation therapy. Oxicams had the least OR of 0.80 (0.73-0.87) for COVID-19 death, followed by ACIs [0.85 (0.77-0.95)] and Biguanides [0.86 (0.82-0.91)].

Conclusion

The chronic use of most frequently used medications for NCDs management was not associated with poor COVID-19 outcomes. Thus, when indicated, physicians need to discourage patients with NCDs from discontinuing their medications for fear of possible adverse effects on COVID-19 prognosis.

SUBMITTER: Malekpour MR

PROVIDER: S-EPMC9998941 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Effect of the chronic medication use on outcome measures of hospitalized COVID-19 patients: Evidence from big data.

Malekpour Mohammad-Reza MR Abbasi-Kangevari Mohsen M Shojaee Ali A Saeedi Moghaddam Sahar S Ghamari Seyyed-Hadi SH Rashidi Mohammad-Mahdi MM Namazi Shabestari Alireza A Effatpanah Mohammad M Nasehi Mohammadmehdi M Rezaei Mehdi M Farzadfar Farshad F

Frontiers in public health 20230224

<h4>Background</h4>Concerns about the role of chronically used medications in the clinical outcomes of the coronavirus disease 2019 (COVID-19) have remarkable potential for the breakdown of non-communicable diseases (NCDs) management by imposing ambivalence toward medication continuation. This study aimed to investigate the association of single or combinations of chronically used medications in NCDs with clinical outcomes of COVID-19.<h4>Methods</h4>This retrospective study was conducted on the ...[more]

PMID: 36908454

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Dataset Information

Effect of the chronic medication use on outcome measures of hospitalized COVID-19 patients: Evidence from big data.

Background

Methods

Findings

Conclusion

Publications

Effect of the chronic medication use on outcome measures of hospitalized COVID-19 patients: Evidence from big data.

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