High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy.

ABSTRACT:

Background

The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. GDM patients have a significantly higher rate of cesarean section and postpartum hemorrhage, suggesting changes in uterine contractility. TWIK-1-related potassium channel (TREK1) expressed in the pregnant uterus and its role in uterine contraction. In this study, we examined the expression of HIF-1α and TREK1 proteins in GDM uterine and investigated whether high glucose levels are involved in the regulation of human uterine smooth muscle cells (HUSMCs) contraction through TREK1, and verified the role of HIF-1α in this process.

Methods

Compared the uterine contractility between GDM and normal patients undergoing elective lower segment cesarean section. The HUSMCs were divided into normal

SUBMITTER: Li T 

PROVIDER: S-EPMC9998977 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature