Constipation and cardiovascular disease: A two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Although several observational studies have suggested positive associations between constipation and cardiovascular disease (CVD), a solid causal association has not been demonstrated. Therefore, a two-sample Mendelian randomization (MR) study was performed to investigate the causal associations between constipation and CVD.

Methods

Independent genetic variants strongly associated with constipation were obtained from the FinnGen consortium. Summary-level data for CVD, including coronary artery disease (CAD), myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), stroke, and its subtypes, were collected from a few extensive genome-wide association studies (GWASs). The inverse-variance weighted methods, weighted median, and MR-Egger were used for

SUBMITTER: Dong Q 

PROVIDER: S-EPMC9998987 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature