Tryptophan metabolism as bridge between gut microbiota and brain in chronic social defeat stress-induced depression mice.

ABSTRACT:

Backgrounds

Gut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to explore the relationships between gut microbiota and host's metabolism in depression.

Methods

Chronic social defeat stress (CSDS) model of depression was established using C57BL/6 male mice. Fecal samples were collected from CSDS group and control group to measure gut microbiota and microbial metabolites. Meanwhile, tryptophan metabolism-related metabolites in hippocampus were also analyzed.

Results

CSDS successfully induced depressive-like behaviors in CSDS group. The 24 differential bacterial taxa between the two groups were identified, and 14 (60.87%) differential bacterial taxa belonged to phy

SUBMITTER: Xie J 

PROVIDER: S-EPMC9999000 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature