Clinical symptoms, thyroid dysfunction, and metabolic disturbances in first-episode drug-naive major depressive disorder patients with suicide attempts: A network perspective.

ABSTRACT:

Backgrounds

Co-occurrence of thyroid dysfunction, metabolic disturbances, and worsening clinical symptoms in major depressive disorder (MDD) patients with suicidal attempts (SA) are common. However, their relationship in SA patients remains unexplored. We aimed to (1) determine the independent association of thyroid dysfunction, clinical symptoms, and metabolic disturbances with SA; and (2) identify their interactions in SA patients via the network approach.

Methods

1718 FEDN MDD patients were recruited. Depressive, anxiety, and psychotic symptoms were assessed by the Hamilton Rating Scale for Depression (HAMD), the Hamilton Rating Scale for Anxiety (HAMA), and the Positive and Negative Syndrome Subscale positive subscale, respectively. The serum levels of thyroid hor

SUBMITTER: Peng P 

PROVIDER: S-EPMC9999007 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature