Oxaloacetate enhances and accelerates regeneration in young mice by promoting proliferation and mineralization.

ABSTRACT: Cell metabolism coordinates the biochemical reactions that produce carbon and ATP in order for the cell to proliferate, differentiate, and respond to environmental changes. Cell type determines metabolic demand, so proliferating skeletal progenitors and differentiated osteoblasts exhibit different levels of cell metabolism. Limb regeneration is an energetically demanding process that involves multiple types of tissues and cell functions over time. Dysregulation of cell metabolism in aged mice results in impaired regeneration, a defect that can be rescued in part by the administration of oxaloacetate (OAA). A better understanding of how cell metabolism regulates regeneration in general, and how these changes can be modulated to benefit potential regenerative strategies in the future is need

SUBMITTER: Jaramillo J 

PROVIDER: S-EPMC9999028 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature