Implementing cone-beam computed tomography-guided online adaptive radiotherapy in cervical cancer.

ABSTRACT:

Background and purpose

Adaptive radiotherapy (ART) in locally advanced cervical cancer (LACC) has shown promising outcomes. This study investigated the feasibility of cone-beam computed tomography (CBCT)-guided online ART (oART) for the treatment of LACC.

Material and methods

The quality of the automated radiotherapy treatment plans and artificial intelligence (AI)-driven contour delineation for LACC on a novel CBCT-guided oART system were assessed. Dosimetric analysis of 200 simulated oART sessions were compared with standard treatment. Feasibility of oART was assessed from the delivery of 132 oART fractions for the first five clinical LACC patients. The simulated and live oART sessions compared a fixed planning target volume (PTV) margin of 1.5 cm around the uterus-cervix

SUBMITTER: Shelley CE 

PROVIDER: S-EPMC9999162 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature