SUMO1 regulates post-infarct cardiac repair based on cellular heterogeneity.

ABSTRACT: Small ubiquitin-related modifier (SUMOylation) is a dynamic post-translational modification that maintains cardiac function and can protect against a hypertrophic response to cardiac pressure overload. However, the function of SUMOylation after myocardial infarction (MI) and the molecular details of heart cell responses to SUMO1 deficiency have not been determined. In this study, we demonstrated that SUMO1 protein was inconsistently abundant in different cell types and heart regions after MI. However, SUMO1 knockout significantly exacerbated systolic dysfunction and infarct size after myocardial injury. Single-nucleus RNA sequencing revealed the differential role of SUMO1 in regulating heart cells. Among cardiomyocytes, SUMO1 deletion increased the Nppa ⁺ Nppb

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9999303 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature