Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) have been used as potential drug targets in preclinical research and clinical trials of various cancers. However, their distribution in Krukenberg tumors (KTs) remains unclear. We investigated the expression and prognostic value of TAMs in patients with gastrointestinal cancer with KTs.

Methods

The infiltration of various types of TAMs was detected in surgical tissues of 35 patients with KTs using immunohistochemical staining. The level of infiltration of TAMs in tumor nests (TN), tumor stroma (TS), and invasive margin (IM) areas was evaluated. The Kaplan-Meier method and univariate/multivariate Cox regression risk models were used to analyze the relationship between the degree of TAMs invasion and overall survival (OS) and prog

SUBMITTER: Huang Z 

PROVIDER: S-EPMC9999382 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature