Directed Biosynthesis of Mitragynine Stereoisomers.
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ABSTRACT:
SUBMITTER: Schotte C
PROVIDER: S-EPMC9999412 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Directed Biosynthesis of Mitragynine Stereoisomers.
Schotte Carsten C Jiang Yindi Y Grzech Dagny D Dang Thu-Thuy T TT Laforest Larissa C LC León Francisco F Mottinelli Marco M Nadakuduti Satya Swathi SS McCurdy Christopher R CR O'Connor Sarah E SE
Journal of the American Chemical Society 20230222 9
<i>Mitragyna speciosa</i> ("kratom") is used as a natural remedy for pain and management of opioid dependence. The pharmacological properties of kratom have been linked to a complex mixture of monoterpene indole alkaloids, most notably mitragynine. Here, we report the central biosynthetic steps responsible for the scaffold formation of mitragynine and related corynanthe-type alkaloids. We illuminate the mechanistic basis by which the key stereogenic center of this scaffold is formed. These disco ...[more]
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