Weight-dependent and weight-independent effects of dulaglutide on blood pressure in patients with type 2 diabetes.

ABSTRACT:

Background

Patients with type 2 diabetes (T2D) treated with glucagon-like peptide-1 receptor agonists may experience reductions in weight and blood pressure. The primary objective of the current study was to determine the weight-dependent and weight-independent effects of ~ 6 months treatment with dulaglutide 1.5 mg treatment in participants with T2D.

Methods

Mediation analysis was conducted for five randomized, placebo-controlled trials of dulaglutide 1.5 mg to estimate the weight-dependent (i.e., mediated by weight) and weight-independent effects from dulaglutide vs. placebo on change from baseline for systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure. A random-effects meta-analysis combined these results. To investigate a dose response betw

SUBMITTER: Ferdinand KC 

PROVIDER: S-EPMC9999488 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature