Associations of genetic markers of diabetes mellitus with carotid atherosclerosis: a community-based case-control study.

ABSTRACT:

Background

Diabetes mellitus (DM) is a well-established determinant of atherosclerosis and cardiovascular diseases (CVD). Recently, genome-wide association studies (GWAS) identified several single nucleotide polymorphism (SNP) significantly correlated with DM. The study aimed to explore the relationships of the top significant DM SNPs with carotid atherosclerosis (CA).

Methods

We used a case-control design and randomly selected 309 cases and 439 controls with and without, respectively, carotid plaque (CP) from a community-based cohort. Eight recent GWAS on DM in East Asians reported hundreds of SNPs with genome-wide significance. The study used the top significant DM SNPs, with a p-value < 10^-16, as the candidate genetic markers of CA. The independent effects of t

SUBMITTER: Wu TW 

PROVIDER: S-EPMC9999522 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature