ISL1 controls pancreatic alpha cell fate and beta cell maturation.

ABSTRACT:

Background

Glucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these endocrine cells remain unclear.

Results

We unravel the molecular mode of action of ISL1 in controlling α cell fate and the formation of functional ß cells in the pancreas. By combining transgenic mouse models, transcriptomic and epigenomic profiling, we uncover that elimination of Isl1 results in a diabetic phenotype with a complete loss of α cells, disrupted pancreatic islet architecture, downregulation of key ß-cell regulators and maturation markers of ß cells, and an enrichment in an intermediate endocrine progenitor transcriptomic profile.

Conclusions

Mechanistically, apart from the altered transcriptome of pancreatic

SUBMITTER: Bohuslavova R 

PROVIDER: S-EPMC9999528 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature