The hsa_circ_0000276-ceRNA regulatory network and immune infiltration in cervical cancer.

ABSTRACT:

Background

Our previous studies have confirmed that miR-154-5p can regulate pRb expression, and thus, play a tumor suppressor role in HPV16 E7-induced cervical cancer. However, its upstream molecules have not been elucidated in the progression of cervical cancer. This study aimed to explore the role of the miR-154-5p upstream molecule, hsa_circ_0000276 in cervical cancer development and its possible mechanisms of action.

Methods

We detected differences in whole transcriptome expression profiles of cervical squamous carcinoma and tissues adjacent to cervical cancer tissues from patients using microarray technology to predict circular RNAs (circRNAs) with binding sites to miR-154-5p. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9999601 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature