Deep phenotyping towards precision psychiatry of first-episode depression - the Brain Drugs-Depression cohort.

ABSTRACT:

Background

Major Depressive Disorder (MDD) is a heterogenous brain disorder, with potentially multiple psychosocial and biological disease mechanisms. This is also a plausible explanation for why patients do not respond equally well to treatment with first- or second-line antidepressants, i.e., one-third to one-half of patients do not remit in response to first- or second-line treatment. To map MDD heterogeneity and markers of treatment response to enable a precision medicine approach, we will acquire several possible predictive markers across several domains, e.g., psychosocial, biochemical, and neuroimaging.

Methods

All patients are examined before receiving a standardised treatment package for adults aged 18-65 with first-episode depression in six public outpatient clinic

SUBMITTER: Jensen KHR 

PROVIDER: S-EPMC9999625 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature