PD-L1 Expression in Medullary Thyroid Carcinoma and Its Association with Clinicopathological Findings.

ABSTRACT: < strong > Objective: < /strong > Medullary thyroid carcinoma (MTC) is a rare tumor originating from parafollicular C cells. It has more aggressive biologic behavior than differentiated thyroid carcinomas, and it is insensitive to treatment with radioactive iodine. Vandetanib and cabozantinib are the newly approved tyrosine kinase inhibitors in advanced stages, but novel effective systemic therapeutics could be crucial and needed for the clinical management of these patients. We aimed to evaluate the Programmed death-ligand 1 (PD-L1) expression, which is a novel immunotherapy target, in our MTC cohort, and determine whether it has an association with clinical and pathological features. < strong > Material and Method: < /strong > This retrospective study involved 41 cases of MTC with a medi

SUBMITTER: Kemal Y 

PROVIDER: S-EPMC9999690 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature