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Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel

ABSTRACT:

SUBMITTER: Roderick MacKinnon 

PROVIDER: EMPIAR-10081 | biostudies-other |

REPOSITORIES: biostudies-other

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Structures of the Human HCN1 Hyperpolarization-Activated Channel.

Lee Chia-Hsueh CH   MacKinnon Roderick R  

Cell 20170112 1-2

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the control of rhythmic activity in cardiac and neuronal pacemaker cells. In HCN, the polarity of voltage dependence is uniquely reversed. Intracellular cyclic adenosine monophosphate (cAMP) levels tune the voltage response, enabling sympathetic nerve stimulation to increase the heart rate. We present cryo-electron microscopy structures of the human HCN channel in the absence and presence of cAMP at 3.5 Å resolution. HCN  ...[more]

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