Dataset Information
RNA Polymerase III pre-initiation complex
Ontology highlight
ABSTRACT:
SUBMITTER: Matthias Vorländer
PROVIDER: EMPIAR-10168 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular mechanism of promoter opening by RNA polymerase III.
Nature 20180101 7688
RNA polymerase III (Pol III) and transcription factor IIIB (TFIIIB) assemble together on different promoter types to initiate the transcription of small, structured RNAs. Here we present structures of Pol III preinitiation complexes, comprising the 17-subunit Pol III and the heterotrimeric transcription factor TFIIIB, bound to a natural promoter in different functional states. Electron cryo-microscopy reconstructions, varying from 3.7 Å to 5.5 Å resolution, include two early intermediates in whi ...[more]