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Cryo-EM structure of alpha-synuclein fibrils

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SUBMITTER: Henning Stahlberg 

PROVIDER: EMPIAR-10195 | biostudies-other |

REPOSITORIES: biostudies-other

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Parkinson's disease is a progressive neuropathological disorder that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found at abnormally high concentrations in affected neurons. Its hallmark are intracellular inclusions called Lewy bodies and Lewy neurites. We here report the structure of cytotoxic alpha-synuclein fibrils (residues 1-121), determined by cryo-electron microscopy at a resolution of 3.4 Å. Two protofilaments form a polar fibril composed of stagger  ...[more]

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