Dataset Information
CryoEM structure of human LRRC8A
Ontology highlight
ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-10196 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of the human volume-regulated anion channel LRRC8.
Nature structural & molecular biology 20180820 9
Maintenance of cell volume against osmotic change is crucial for proper cell functions. Leucine-rich repeat-containing 8 proteins are anion-selective channels that extrude anions to decrease the cell volume on cellular swelling. Here, we present the structure of human leucine-rich repeat-containing 8A, determined by single-particle cryo-electron microscopy. The structure shows a hexameric assembly, and the transmembrane region features a topology similar to gap junction channels. The LRR region, ...[more]
