Dataset Information
LAT1-CD98hc bound to HBJ127 Fab and MEM-108 Fab
Ontology highlight
ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-10265 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc.
Nature structural & molecular biology 20190603 6
The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a disulfide-linked heterodimer with CD98 heavy chain (CD98hc, 4F2hc or SLC3A2), but the mechanism of assembly and amino acid transport are poorly understood. Here we report the cryo-EM structure of the human LAT1-CD98hc heterodimer at 3.3-Å resolution. LAT1 features a canonical Leu T-fold and exhibits an unusual loop str ...[more]
