Dataset Information
3.2 Å Single-Particle Cryo-EM Reconstruction of 49 kDa Membrane-Bound PfCRT Complexed with Fab
Ontology highlight
ABSTRACT:
SUBMITTER: Yong Zi Tan
PROVIDER: EMPIAR-10330 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature 20191127 7786
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia and South America and spread worldwide<sup>1</sup>. Clinical resistance to the chemically related current first-line combination drug piperaquine (P ...[more]
