Dataset Information
Multiple Genomic RNA-Coat Protein Contacts Play Vital Roles in the Assembly of Infectious Enterovirus-E
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ABSTRACT:
SUBMITTER: Peter G. Stockley
PROVIDER: EMPIAR-10341 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Assembly of infectious enteroviruses depends on multiple, conserved genomic RNA-coat protein contacts.
PLoS pathogens 20201228 12
Picornaviruses are important viral pathogens, but despite extensive study, the assembly process of their infectious virions is still incompletely understood, preventing the development of anti-viral strategies targeting this essential part of the life cycle. We report the identification, via RNA SELEX and bioinformatics, of multiple RNA sites across the genome of a typical enterovirus, enterovirus-E (EV-E), that each have affinity for the cognate viral capsid protein (CP) capsomer. Many of these ...[more]