Dataset Information
Human delta protocadherin 1 full ectodomains on membranes, tomogram 2
Ontology highlight
ABSTRACT:
SUBMITTER: Lawrence Shapiro
PROVIDER: EMPIAR-10368 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.
Cell reports 20200201 8
Non-clustered δ1- and δ2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions, we used solution biophysics to characterize binding of δ1- and δ2-protocadherins, determined crystal structures of ectodomain complexes from each family, and assessed ectodomain assembly in reconstituted intermembrane junctions by cryoelectron tomography (cry ...[more]