Dataset Information
SARS-CoV-2 productively infects human gut enterocytes
Ontology highlight
ABSTRACT:
SUBMITTER: Kèvin Knoops
PROVIDER: EMPIAR-10404 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
SARS-CoV-2 productively infects human gut enterocytes.
Science (New York, N.Y.) 20200501 6499
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocyt ...[more]
