Dataset Information
Structure of replicating SARS-CoV-2 polymerase
Ontology highlight
ABSTRACT:
SUBMITTER: Patrick Cramer
PROVIDER: EMPIAR-10409 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of replicating SARS-CoV-2 polymerase.
Nature 20200521 7819
The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes<sup>1-3</sup>. Here we present a cryo-electron microscopy structure of the SARS-CoV-2 RdRp in an active form that mimics the replicating enzyme. The structure comprises the viral proteins non-structural protein 12 (nsp12), nsp8 and nsp7, and more than two turns of RNA template-product duplex. The active-s ...[more]