Dataset Information
Structure of the Bacterial Ribosome at 2 Å Resolution
Ontology highlight
ABSTRACT:
SUBMITTER: Jamie HD Cate
PROVIDER: EMPIAR-10509 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the bacterial ribosome at 2 Å resolution.
eLife 20200914
Using cryo-electron microscopy (cryo-EM), we determined the structure of the <i>Escherichia coli</i> 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous positioning of protein and RNA residues, their detailed chemical interactions, and chemical modifications. Notable features include the first examples of isopeptide and thioamide backbone substitutions in ribosomal proteins, the former likely conserved in all domains of life. The maps also reveal extensive solvation of th ...[more]