Dataset Information
Cryo-EM structure of immunodominant protein P1 from human pathogen Mycoplasma pneumoniae on graphene oxide grid
Ontology highlight
ABSTRACT:
SUBMITTER: Makoto Miyata
PROVIDER: EMPIAR-10518 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.
Nature communications 20201014 1
Mycoplasma pneumoniae is a bacterial human pathogen that causes primary atypical pneumonia. M. pneumoniae motility and infectivity are mediated by the immunodominant proteins P1 and P40/P90, which form a transmembrane adhesion complex. Here we report the structure of P1, determined by X-ray crystallography and cryo-electron microscopy, and the X-ray structure of P40/P90. Contrary to what had been suggested, the binding site for sialic acid was found in P40/P90 and not in P1. Genetic and clinical ...[more]